The factor of stimulation of colonies of granulocytes-macrophages (rHuGM-CSF) is used in febrile leukopenic patients to promote the production of leucocytes. Il peut amorcer les monocytes au repos et augmenter leur réponse inflammatoire . It regulates the strengthening of the HLA-DR expression, the secretion of TNF-a monocytes induces LPS, and the regulation of the release of anti-inflammatory cytokines .
Twenty septic patients, mean age 64.8 ± 3.7 (14 males) and disease severity score, SAPS II, 43.5 ± 4.5 received subcutaneous mogra most in 200 µg every 12 h for 3 consecutive days. We observed an increase in the leukocyte count and course of the PaO2/FiO2 index with the same FiO2.